Anti-ALKBH8 Antibody

Alkylated DNA repair protein alkB homolog 8;1.14.11.-; Probable alpha-ketoglutarate-dependent dioxygenase ABH8; S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8; tRNA (carboxymethyluridine (34) -5-O) -methyltransferase ABH8;2.1.1.229; ALKBH8; ABH8;

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323) . Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323) . Has a preference for tRNA (Arg) and tRNA (Glu), and does not bind tRNA (Lys) (PubMed:20308323) . Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5- (S) -methoxycarbonylhydroxymethyluridine; has a preference for tRNA (Gly) (PubMed:21285950) . Required for normal survival after DNA damage (PubMed:20308323) . May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182) .