Anti-ALKBH8 Antibody
Boster Bio Anti-ALKBH8 Antibody catalog # A09491. Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
Alkylated DNA repair protein alkB homolog 8;1.14.11.-; Probable alpha-ketoglutarate-dependent dioxygenase ABH8; S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8; tRNA (carboxymethyluridine (34) -5-O) -methyltransferase ABH8;2.1.1.229; ALKBH8; ABH8;
Gene Name
ALKBH8
UniProt
Q96BT7
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant protein of human ALKBH8.
Clonality
Polyclonal
Tissue Specificity
Widely expressed, with highest expression in spleen, followed by pancreas and lung.
Applications
WB, IHC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323) . Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323) . Has a preference for tRNA (Arg) and tRNA (Glu), and does not bind tRNA (Lys) (PubMed:20308323) . Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5- (S) -methoxycarbonylhydroxymethyluridine; has a preference for tRNA (Gly) (PubMed:21285950) . Required for normal survival after DNA damage (PubMed:20308323) . May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182) .
Molecular Weight
75208 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Alkylated DNA repair protein alkB homolog 8
Subcellular Location
Cytoplasm
Protein Name
Alkylated DNA repair protein alkB homolog 8
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