Anti-Apolipoprotein B receptor APOBR Antibody

Boster Bio Anti-Apolipoprotein B receptor APOBR Antibody catalog # A09242. Tested in WB, IHC applications. This antibody reacts with Human, Rat.

Product Specifications

Synonyms

Apolipoprotein B receptor; Apolipoprotein B-100 receptor; Apolipoprotein B-48 receptor; Apolipoprotein B48 receptor; apoB-48R; APOBR; APOB48R;

Gene Name

APOBR

UniProt

Q0VD83

Host

Rabbit

Reactivity

Human, Rat

Immunogen

A synthetic peptide corresponding to residues in Human APOBR

Clonality

Polyclonal

Tissue Specificity

Expressed in peripheral blood leukocytes > bone marrow = spleen > lymph node, and only faintly visible in appendix and thymus. Expressed in the brain, heart, kidney, liver, lung, pancreas, and placenta. Expressed primarily by reticuloendothelial cells: monocytes, macrophages, and endothelial cells. Expressed in atherosclerotic lesion foam cells.

Applications

WB, IHC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Form

Liquid

Function

Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG) -rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL) . Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP) . Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG- VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages.