Anti-BNIP1 Antibody

Vesicle transport protein SEC20; BCL2/adenovirus E1B 19 kDa protein-interacting protein 1; Transformation-related gene 8 protein; TRG-8; BNIP1; NIP1, SEC20L; TRG8;

Isoform 1 is highly expressed in heart, brain, liver skeletal muscle and pancreas. Isoform 3 is moderately expressed in placenta, lung and kidney. Isoform 4 is highly expressed in testis and small intestine.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization (PubMed:15272311) . Plays also a role in apoptosis (PubMed:7954800, PubMed:15272311, PubMed:23896122) . It is for instance required for endoplasmic reticulum stress-induced apoptosis (PubMed:23896122) . As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable) .