Anti-CIAO1 Antibody
Boster Bio Anti-CIAO1 Antibody catalog # A09213. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Probable cytosolic iron-sulfur protein assembly protein CIAO1
Gene Name
CIAO1
UniProt
O76071
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant full length Human CIAO1.
Clonality
Polyclonal
Applications
WB, IHC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:17937914, PubMed:23891004) . As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures ACO1 and stabilizes IREB2 (PubMed:23891004) . Seems to specifically modulate the transactivation activity of WT1 (PubMed:9556563) . As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (PubMed:20797633) .
Molecular Weight
37840 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Probable cytosolic iron-sulfur protein assembly protein CIAO1
Subcellular Location
Cytoplasm
Protein Name
Probable cytosolic iron-sulfur protein assembly protein CIAO1
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