Anti-AHCYL1 Antibody

Boster Bio Anti-AHCYL1 Antibody catalog # A08908-1. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

S-adenosylhomocysteine hydrolase-like protein 1

Gene Name

AHCYL1

UniProt

O43865

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human AHCYL1.

Clonality

Polyclonal

Tissue Specificity

Expressed in dendritic cells.

Applications

WB, IHC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Form

Liquid

Function

Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3 (-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5- trisphosphate competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5- trisphosphate-induced calcium release by interacting with ITPR1 (PubMed:16793548) . When extracellular stimuli induce ITPR1 phosphorylation or inositol 1,4,5-trisphosphate production, dissociates of ITPR1 to interact with CFTR and SLC26A6 mediating their synergistic activation by calcium and cAMP that stimulates the epithelial secretion of electrolytes and fluid (By similarity) . Also activates basolateral SLC4A4 isoform 1 to coordinate fluid and HCO3 (-) secretion (PubMed:16769890) . Inhibits the effect of STK39 on SLC4A4 and CFTR by recruiting PP1 phosphatase which activates SLC4A4, SLC26A6 and CFTR through dephosphorylation (By similarity) . Mediates the induction of SLC9A3 surface expression produced by Angiotensin-2 (PubMed:20584908) . Depending on the cell type, activates SLC9A3 in response to calcium or reverses SLC9A3R2-dependent calcium inhibition (PubMed:18829453) . May modulate the polyadenylation state of specific mRNAs, both by controlling the subcellular location of FIP1L1 and by inhibiting PAPOLA activity, in response to a stimulus that alters its phosphorylation state (PubMed:19224921) . Acts as a (dATP) -dependent inhibitor of ribonucleotide reductase large subunit RRM1, controlling the endogenous dNTP pool and ensuring normal cell cycle progression (PubMed:25237103) . In vitro does not exhibit any S-adenosyl-L- homocysteine hydrolase activity (By similarity) .