Anti-DNA polymerase delta subunit 4 POLD4 Antibody

Boster Bio Anti-DNA polymerase delta subunit 4 POLD4 Antibody catalog # A08778. Tested in WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

DNA polymerase delta subunit 4; DNA polymerase delta subunit p12; POLD4; POLDS;

Gene Name

POLD4

UniProt

Q9HCU8

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant fusion protein of human POLD4 (NP_066996.3) .

Clonality

Polyclonal

Applications

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Dilution

WB: 1:500-1:2000

Form

Liquid

Function

As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity (PubMed:16510448, PubMed:19074196, PubMed:20334433) . Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system (PubMed:24035200) . Under conditions of DNA replication stress, required for the repair of broken replication forks through break- induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb (PubMed:24310611) . Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites (PubMed:19074196) . Its degradation in response to DNA damage is required for the inhibition of fork progression and cell survival (PubMed:24022480) .