Anti-CALCOCO1 Antibody

Boster Bio Anti-CALCOCO1 Antibody catalog # A08702. Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Calcium-binding and coiled-coil domain-containing protein 1; Calphoglin; Coiled-coil coactivator protein; Sarcoma antigen NY-SAR-3; CALCOCO1; KIAA1536; PP13275, UNQ2436/PRO4996;

Gene Name

CALCOCO1

UniProt

Q9P1Z2

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human CALCOCO1.

Clonality

Polyclonal

Applications

WB, IHC, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Form

Liquid

Function

Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR) . Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1- mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity) . In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781) .