Anti-NACC1 Antibody

Boster Bio Anti-NACC1 Antibody catalog # A08675-1. Tested in WB, IHC applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Nucleus accumbens-associated protein 1; NAC-1; BTB/POZ domain-containing protein 14B; NACC1; BTBD14B, NAC1;

Gene Name

NACC1

UniProt

Q96RE7

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant fusion protein of human NACC1 (NP_443108.1) .

Clonality

Polyclonal

Tissue Specificity

Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer.

Applications

WB, IHC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Form

Liquid

Function

Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.