Anti-Cables1 (K588) Antibody
Boster Bio Anti-Cables1 (K588) Antibody catalog # A08581-1. Tested in IHC, IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
CDK5 and ABL1 enzyme substrate 1; Interactor with CDK3 1; Ik3-1; CABLES1; CABLES;
Gene Name
CABLES1
UniProt
Q8TDN4
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 550-600 of Human Cables1.
Clonality
Polyclonal
Tissue Specificity
Expressed in breast, pancreas, colon, head and neck (at protein level) . Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers.
Applications
IHC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity) . .
Molecular Weight
67599 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A08581-1
Product MSDS
https://www.bosterbio.com/msds?sku=A08581-1
Other Gene Names
CDK5 and ABL1 enzyme substrate 1
Subcellular Location
Nucleus . Cytoplasm . Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity) . .
Protein Name
CDK5 and ABL1 enzyme substrate 1
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