Anti-EMR2 (L160) ADGRE2 Antibody

Boster Bio Anti-EMR2 (L160) ADGRE2 Antibody catalog # A08546-1. Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Adhesion G protein-coupled receptor E2

Gene Name

ADGRE2

UniProt

Q9UHX3

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 130-178 of Human EMR2.

Clonality

Polyclonal

Tissue Specificity

Expression is restricted to myeloid cells. Highest expression was found in peripheral blood leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal liver, placenta, and lung, and no expression in heart, brain, skeletal muscle, kidney, or pancreas. Expression is also detected in monocyte/macrophage and Jurkat cell lines but not in other cell lines tested. High expression in mast cells (PubMed:26841242) .

Applications

WB, IHC, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Form

Liquid

Function

Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G- proteins. Is a regulator of mast cell degranulation (PubMed:26841242) .