Anti-TTC3 Antibody
Boster Bio Anti-TTC3 Antibody catalog # A08132. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
E3 ubiquitin-protein ligase TTC3;2.3.2.27; Protein DCRR1; RING finger protein 105; RING-type E3 ubiquitin transferase TTC3 ; TPR repeat protein D; Tetratricopeptide repeat protein 3; TPR repeat protein 3; TTC3; DCRR1, RNF105, TPRD;
Gene Name
TTC3
UniProt
P53804
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein of human TTC3
Clonality
Polyclonal
Tissue Specificity
Found in all tissues examined.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:500-1:2000
Form
Liquid
Function
E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'- polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.
Molecular Weight
229869 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A08132
Product MSDS
https://www.bosterbio.com/msds?sku=A08132
Other Gene Names
E3 ubiquitin-protein ligase TTC3
Subcellular Location
Nucleus
Protein Name
E3 ubiquitin-protein ligase TTC3
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