Anti-IBTK Antibody
Boster Bio Anti-IBTK Antibody catalog # A07985. Tested in WB applications. This antibody reacts with Human.
Product Specifications
Synonyms
Inhibitor of Bruton tyrosine kinase; IBtk; IBTK; BTKI, KIAA1417;
Gene Name
IBTK
UniProt
Q9P2D0
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant fusion protein of human IBTK (NP_056340.2) .
Clonality
Polyclonal
Tissue Specificity
Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level) . Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow) . Weakly or not expressed in other tissues.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:500-1:2000
Form
Liquid
Function
Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription.
Molecular Weight
150528 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Inhibitor of Bruton tyrosine kinase
Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein. Translocates to the plasma membrane upon IgM stimulation.
Protein Name
Inhibitor of Bruton tyrosine kinase
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