Anti-SEC61A1 Antibody
Boster Bio Anti-SEC61A1 Antibody catalog # A07764. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Protein transport protein Sec61 subunit alpha isoform 1; Sec61 alpha-1; SEC61A1; SEC61A;
Gene Name
SEC61A1
UniProt
P61619
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human SEC61A1 (NP_037468.1) .
Clonality
Polyclonal
Tissue Specificity
Expressed in proximal and distal tubules in kidney (at protein level) .
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:500-1:2000
Form
Liquid
Function
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER) . Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:22375059, PubMed:28782633, PubMed:29719251) . May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post- translational transport of small presecretory proteins (PubMed:22375059, PubMed:29719251) . Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (PubMed:28782633) . Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity) .
Molecular Weight
52265 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Protein transport protein Sec61 subunit alpha isoform 1
Subcellular Location
Endoplasmic reticulum membrane
Protein Name
Protein transport protein Sec61 subunit alpha isoform 1
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