Anti-USP37 Antibody
Boster Bio Anti-USP37 Antibody catalog # A07535. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Ubiquitin carboxyl-terminal hydrolase 37;3.4.19.12
Gene Name
USP37
UniProt
Q86T82
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 702-747 of Human USP37.
Clonality
Polyclonal
Tissue Specificity
Expressed in brain and prostate.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:500-1:1000
Form
Liquid
Function
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'- linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315) . Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872) .
Molecular Weight
110170 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Ubiquitin carboxyl-terminal hydrolase 37
Protein Name
Ubiquitin carboxyl-terminal hydrolase 37
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