Anti-Ksr2 (I694) Antibody
Boster Bio Anti-Ksr2 (I694) Antibody catalog # A06876-1. Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Kinase suppressor of Ras 2; hKSR2;2.7.11.1; KSR2;
Gene Name
KSR2
UniProt
Q6VAB6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 662-724 of Human Ksr2.
Clonality
Polyclonal
Tissue Specificity
Mainly expressed in brain and kidney.
Applications
WB, IHC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro) . Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro) . Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
Molecular Weight
107632 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Kinase suppressor of Ras 2
Subcellular Location
Cytoplasm . Membrane ; Peripheral membrane protein .
Protein Name
Kinase suppressor of Ras 2
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