Anti-Integrin beta-8 ITGB8 Antibody
Boster Bio Anti-Integrin beta-8 ITGB8 Antibody catalog # A06744. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Integrin beta-8 ; ITGB8
Gene Name
ITGB8
UniProt
P26012
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human ITGB8 (NP_002205.1) .
Clonality
Polyclonal
Tissue Specificity
Placenta, kidney, brain, ovary, uterus and in several transformed cells. Transiently expressed in 293 human embryonic kidney cells.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:500-1:2000
Form
Liquid
Function
Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (PubMed:1918072) . It recognizes the sequence R-G-D in its ligands (PubMed:1918072) . Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency- associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable) . Required during vasculogenesis (By similarity) .
Molecular Weight
85632 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Integrin beta-8
Subcellular Location
Cell membrane
Protein Name
Integrin beta-8
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