Anti-CNDP2 Antibody

Boster Bio Anti-CNDP2 Antibody catalog # A06331. Tested in WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Cytosolic non-specific dipeptidase;3.4.13.18; CNDP dipeptidase 2; Carnosine dipeptidase II

Gene Name

CNDP2

UniProt

Q96KP4

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant full length protein of human CNDP2

Clonality

Polyclonal

Tissue Specificity

Isoform 1 is ubiquitously expressed with higher levels in kidney and liver (at protein level) . Expressed in peripheral blood leukocytes (PubMed:12473676) . Isoform 2 is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. Down-regulated in gastric cancer tissues (at protein level) (PubMed:24395568) .

Applications

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Dilution

WB: 1:500-1:2000

Form

Liquid

Function

Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly (PubMed:19346245) . Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation (PubMed:24395568) . Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (PubMed:17121880) . Catalyzes the production of N- lactoyl-amino acids from lactate and amino acids by reverse proteolysis (PubMed:25964343) .