Anti-FANCL Antibody
Boster Bio Anti-FANCL Antibody catalog # A06164. Tested in WB applications. This antibody reacts with Mouse.
Product Specifications
Synonyms
E3 ubiquitin-protein ligase FANCL;2.3.2.27
Gene Name
FANCL
UniProt
Q9NW38
Host
Rabbit
Reactivity
Mouse
Immunogen
Recombinant fusion protein of human FANCL (NP_060532.2) .
Clonality
Polyclonal
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:200-1:2000
Form
Liquid
Function
Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway (PubMed:12973351, PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:24389026) . Also mediates monoubiquitination of FANCI (PubMed:19589784) . May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.
Molecular Weight
42905 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
E3 ubiquitin-protein ligase FANCL
Subcellular Location
Cytoplasm. Nucleus.
Protein Name
E3 ubiquitin-protein ligase FANCL
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