Anti-GRIM19 NDUFA13 Antibody

Boster Bio Anti-GRIM19 NDUFA13 Antibody catalog # A05981-1. Tested in WB, IHC, ICC applications. This antibody reacts with Human.

Product Specifications

Synonyms

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; Cell death regulatory protein GRIM-19; Complex I-B16.6; CI-B16.6; Gene associated with retinoic and interferon-induced mortality 19 protein; GRIM-19; Gene associated with retinoic and IFN-induced mortality 19 protein; NADH-ubiquinone oxidoreductase B16.6 subunit; NDUFA13; GRIM19; CDA016, CGI-39;

Gene Name

NDUFA13

UniProt

Q9P0J0

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant protein within human GRIM19 aa 1-150.

Clonality

Polyclonal

Tissue Specificity

Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis.

Applications

WB, IHC, ICC

Purification

ProA affinity purified

Form

Liquid

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371) . Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371) . Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091) .