Anti-ATP6V0A2 Antibody
Boster Bio Anti-ATP6V0A2 Antibody catalog # A05969. Tested in WB applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
V-type proton ATPase 116 kDa subunit a isoform 2; V-ATPase 116 kDa isoform a2; Lysosomal H (+) -transporting ATPase V0 subunit a2; TJ6; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2; ATP6V0A2;
Gene Name
ATP6V0A2
UniProt
Q9Y487
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A synthetic peptide corresponding to residues in Human ATP6V0A2.
Clonality
Polyclonal
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 102% (by SDS-PAGE) .
Dilution
WB: 1:500-1:1000
Form
Liquid
Function
Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe (2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633) .
Molecular Weight
98082 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
V-type proton ATPase 116 kDa subunit a isoform 2
Subcellular Location
Cell membrane; Multi-pass membrane protein. Endosome membrane. In kidney proximal tubules, also detected in subapical vesicles. .
Protein Name
V-type proton ATPase 116 kDa subunit a isoform 2
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