Anti-SULT2B1 Antibody

Sulfotransferase family cytosolic 2B member 1; ST2B1; Sulfotransferase 2B1;2.8.2.2; Alcohol sulfotransferase; Hydroxysteroid sulfotransferase 2; SULT2B1; HSST2;

Expressed in the stratum granulosum-stratum corneum junction in the skin (at protein level) . Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648) .