Anti-SMUG1 Antibody
Boster Bio Anti-SMUG1 Antibody catalog # A05626. Tested in WB, IHC, ICC applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Single-strand selective monofunctional uracil DNA glycosylase;3.2.2.-; SMUG1;
Gene Name
SMUG1
UniProt
Q53HV7
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 137-182 of Human SMUG1.
Clonality
Polyclonal
Applications
WB, IHC, ICC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A) . Excises uracil (U), 5- formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU) ] in ssDNA and dsDNA, but not analogous cytosine derivatives (5- hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration.
Molecular Weight
29862 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Single-strand selective monofunctional uracil DNA glycosylase
Subcellular Location
Nucleus
Protein Name
Single-strand selective monofunctional uracil DNA glycosylase
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