Anti-SMUG1 Antibody

Boster Bio Anti-SMUG1 Antibody catalog # A05626. Tested in WB, IHC, ICC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Single-strand selective monofunctional uracil DNA glycosylase;3.2.2.-; SMUG1;

Gene Name

SMUG1

UniProt

Q53HV7

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 137-182 of Human SMUG1.

Clonality

Polyclonal

Applications

WB, IHC, ICC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Form

Liquid

Function

Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A) . Excises uracil (U), 5- formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU) ] in ssDNA and dsDNA, but not analogous cytosine derivatives (5- hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration.

Molecular Weight

29862 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A05626

Product MSDS

https://www.bosterbio.com/msds?sku=A05626

Other Gene Names

Single-strand selective monofunctional uracil DNA glycosylase

Subcellular Location

Nucleus

Protein Name