Anti-Galectin 8 LGALS8 Antibody

Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878) . Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878) . Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878) . Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324) . Also required to restrict infection of Picornaviridae viruses (PubMed:28077878) . Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed:21288902) .