Anti-IL31RA Antibody

Interleukin-31 receptor subunit alpha; IL-31 receptor subunit alpha; IL-31R subunit alpha; IL-31R-alpha; IL-31RA; Cytokine receptor-like 3; GLM-R; hGLM-R; Gp130-like monocyte receptor; Gp130-like receptor; ZcytoR17; IL31RA; CRL3, GPL; UNQ6368/PRO21073/PRO21384;

Expressed in CD14- and CD56-positive blood cells (PubMed:11877449) . Expressed in macrophages (PubMed:16461143, PubMed:18439099) . Expressed in keratinocytes (PubMed:21261663) . Expressed in a subset of dorsal root ganglia neurons (at protein level) (PubMed:24373353) . Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin (PubMed:15184896, PubMed:11877449, PubMed:14504285) . Expressed in bronchial and alveolar epithelial cells and pulmonary fibroblasts (PubMed:18439099) . Detected in all of the myelomonocytic lineage (PubMed:14504285) . Isoform 6: Expressed at higher levels in lesional skin compared to healthy skin of atopic dermatitis patients (PubMed:24373353) .

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 (PubMed:11877449, PubMed:14504285, PubMed:15627637, PubMed:15194700) . May function in skin immunity (PubMed:15184896) . Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity) . Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity) .