Anti-MYLIP Antibody

Boster Bio Anti-MYLIP Antibody catalog # A05031-1. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

E3 ubiquitin-protein ligase MYLIP;2.3.2.27; Inducible degrader of the LDL-receptor; Idol; Myosin regulatory light chain interacting protein; MIR; RING-type E3 ubiquitin transferase MYLIP ; MYLIP; BZF1, IDOL; BM-023, PP5242;

Gene Name

MYLIP

UniProt

Q8WY64

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein of human MYLIP (NP_037394.2) .

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed.

Applications

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Dilution

WB: 1:500-1:2000

Form

Liquid

Function

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol- dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

Molecular Weight

49910 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A05031-1

Product MSDS

https://www.bosterbio.com/msds?sku=A05031-1

Other Gene Names

E3 ubiquitin-protein ligase MYLIP

Subcellular Location

Cytoplasm

Protein Name