Anti-CARD14 Antibody
Boster Bio Anti-CARD14 Antibody catalog # A04906-1. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Caspase recruitment domain-containing protein 14; CARD-containing MAGUK protein 2; Carma 2; CARD14; CARMA2;
Gene Name
CARD14
UniProt
Q9BXL6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues in Human CARD14.
Clonality
Polyclonal
Tissue Specificity
Isoform 1 is detected in placenta and epidermal keratinocytes (PubMed:22521418) . Isoform 2 is detected in leukocytes and fetal brain (PubMed:22521418) .
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:500-1:1000
Form
Liquid
Function
Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14- induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27113748, PubMed:27071417) . May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis.
Molecular Weight
113270 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Caspase recruitment domain-containing protein 14
Subcellular Location
Isoform 1: Cytoplasm
Protein Name
Caspase recruitment domain-containing protein 14
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