Anti-NOLC1 Antibody
Boster Bio Anti-NOLC1 Antibody catalog # A04778-1. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Nucleolar and coiled-body phosphoprotein 1 ;140 kDa nucleolar phosphoprotein
Gene Name
NOLC1
UniProt
Q14978
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human NOLC1 (NP_004732.2) .
Clonality
Polyclonal
Applications
WB, IHC, ICC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832) . Required for neural crest specification: following monoubiquitination by the BCR (KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832) . Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786) . It has intrinsic GTPase and ATPase activities (PubMed:9016786) .
Molecular Weight
73603 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Nucleolar and coiled-body phosphoprotein 1
Subcellular Location
Nucleus, nucleolus
Protein Name
Nucleolar and coiled-body phosphoprotein 1
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