Anti-HAND2 Antibody

Boster Bio Anti-HAND2 Antibody catalog # A04652. Tested in WB, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Heart- and neural crest derivatives-expressed protein 2; Class A basic helix-loop-helix protein 26; bHLHa26; Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; dHAND; HAND2; BHLHA26, DHAND;

Gene Name

HAND2

UniProt

P61296

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human HAND2 (NP_068808.1) .

Clonality

Polyclonal

Tissue Specificity

Heart.

Applications

WB, ICC, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Form

Liquid

Function

Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity) . .