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Anti-PEN2 PSENEN Antibody

Boster Bio Anti-PEN2 PSENEN Antibody catalog # A04504-1. Tested in WB, ICC, IHC, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Gamma-secretase subunit PEN-2; Presenilin enhancer protein 2; PSENEN; PEN2; MDS033;

Gene Name

PSENEN

UniProt

Q9NZ42

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to C-terminal human PEN2.

Clonality

Polyclonal

Tissue Specificity

Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain.

Applications

WB, ICC, IHC, Flow Cytometry

Purification

ProA affinity purified

Form

Liquid

Function

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111) . The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable) . PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111) .

Molecular Weight

12029 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A04504-1

Product MSDS

https://www.bosterbio.com/msds?sku=A04504-1

Other Gene Names

Gamma-secretase subunit PEN-2

Subcellular Location

Endoplasmic reticulum membrane

Protein Name

Gamma-secretase subunit PEN-2

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