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Anti-MLK3 (phospho-T277/S281) MAP3K11 Antibody

Boster Bio Anti-MLK3 (phospho-T277/S281) MAP3K11 Antibody catalog # A04412T277S281. Tested in WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Mitogen-activated protein kinase kinase kinase 11;2.7.11.25; Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase; MAP3K11

Gene Name

MAP3K11

UniProt

Q16584

Host

Rabbit

Reactivity

Human

Immunogen

Synthetic phosphopeptide derived from human MLK3 around the phosphorylation site of Threonine 277 / Serine 281.

Clonality

Polyclonal

Tissue Specificity

Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain.

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Dilution

WB: 1:1000-1:2000

Form

Liquid

Function

Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.

Molecular Weight

92688 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

Mitogen-activated protein kinase kinase kinase 11

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

Protein Name

Mitogen-activated protein kinase kinase kinase 11

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