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Anti-USP4 Antibody

Boster Bio Anti-USP4 Antibody catalog # A04324. Tested in WB applications. This antibody reacts with Mouse.

Product Specifications

Synonyms

Ubiquitin carboxyl-terminal hydrolase 4;3.4.19.12

Gene Name

USP4

UniProt

Q13107

Host

Rabbit

Reactivity

Mouse

Immunogen

Recombinant fusion protein of human USP4 (NP_003354.2) .

Clonality

Polyclonal

Tissue Specificity

Overexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung (at protein level) . Expressed in the hippocampal neurons.

Applications

WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Dilution

WB: 1:500-1:2000

Form

Liquid

Function

Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins (PubMed:16316627, PubMed:16472766, PubMed:16339847, PubMed:20595234, PubMed:22347420, PubMed:25404403) . Deubiquitinates PDPK1 (PubMed:22347420) . Deubiquitinates TRIM21 (PubMed:16316627) . Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface (PubMed:16339847) . May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3 (PubMed:20595234) . This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP (PubMed:20595234) . May also play a role in the regulation of quality control in the ER (PubMed:16339847) .

Molecular Weight

108565 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

Ubiquitin carboxyl-terminal hydrolase 4

Subcellular Location

Cytoplasm

Protein Name

Ubiquitin carboxyl-terminal hydrolase 4

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