Anti-PARG Antibody
Boster Bio Anti-PARG Antibody catalog # A04301. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Poly (ADP-ribose) glycohydrolase;3.2.1.143; PARG;
Gene Name
PARG
UniProt
Q86W56
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human PARG (NP_003622.2) .
Clonality
Polyclonal
Tissue Specificity
Ubiquitously expressed.
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:1000-1:2000
Form
Liquid
Function
Poly (ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly (ADP-ribose) glycohydrolase (PubMed:23102699) . PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP- ribose monomers (PubMed:23102699) . Required for retinoid acid- dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR- dependent gene promoters (PubMed:23102699) . Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257) . Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257) .
Molecular Weight
111110 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A04301
Product MSDS
https://www.bosterbio.com/msds?sku=A04301
Other Gene Names
Poly (ADP-ribose) glycohydrolase
Subcellular Location
Isoform 1: Nucleus
Protein Name
Poly (ADP-ribose) glycohydrolase
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