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Anti-WTAP (H351) Antibody

Boster Bio Anti-WTAP (H351) Antibody catalog # A04296-1. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Pre-mRNA-splicing regulator WTAP ; Female-lethal (2) D homolog

Gene Name

WTAP

UniProt

Q15007

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 320-374 of Human WTAP.

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed.

Applications

IHC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Dilution

IHC: 1:50-1:200

Form

Liquid

Function

Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755) . Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863) . Acts as a mRNA splicing regulator (PubMed:12444081) . Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532) . Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724) .

Molecular Weight

44244 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A04296-1

Product MSDS

https://www.bosterbio.com/msds?sku=A04296-1

Other Gene Names

Pre-mRNA-splicing regulator WTAP

Subcellular Location

Nucleus speckle

Protein Name

Pre-mRNA-splicing regulator WTAP

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