Anti-WTAP (H351) Antibody
Boster Bio Anti-WTAP (H351) Antibody catalog # A04296-1. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Pre-mRNA-splicing regulator WTAP ; Female-lethal (2) D homolog
Gene Name
WTAP
UniProt
Q15007
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 320-374 of Human WTAP.
Clonality
Polyclonal
Tissue Specificity
Ubiquitously expressed.
Applications
IHC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
IHC: 1:50-1:200
Form
Liquid
Function
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755) . Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863) . Acts as a mRNA splicing regulator (PubMed:12444081) . Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532) . Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724) .
Molecular Weight
44244 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Pre-mRNA-splicing regulator WTAP
Subcellular Location
Nucleus speckle
Protein Name
Pre-mRNA-splicing regulator WTAP
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