Anti-NUDT1 Antibody

Boster Bio Anti-NUDT1 Antibody catalog # A04258-1. Tested in WB, IP applications. This antibody reacts with Human.

Product Specifications

Synonyms

7,8-dihydro-8-oxoguanine triphosphatase;3.6.1.55

Gene Name

NUDT1

UniProt

P36639

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant fusion protein of human MTH1 (NP_945192.1) .

Clonality

Polyclonal

Tissue Specificity

Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.

Applications

WB, IP

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Form

Liquid

Function

Antimutagenic (PubMed:8226881, PubMed:7713500, PubMed:10608900) . Plays a redundant role in sanitizing oxidized nucleotide pools, such as 8-oxo-dGTP pools (PubMed:28679043) . Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress (PubMed:12857738, PubMed:24695224, PubMed:24695225) . Hydrolyzes 8- oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions (PubMed:8226881, PubMed:10373420, PubMed:10608900, PubMed:11756418, PubMed:12857738, PubMed:16607562, PubMed:24695224, PubMed:24695225, PubMed:26999531, PubMed:28035004) . Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP (PubMed:10373420, PubMed:11139615) . Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity) .