Anti-Myelin transcription factor 1 MYT1 Antibody

Myelin transcription factor 1; MyT1; Myelin transcription factor I; MyTI; PLPB1; Proteolipid protein-binding protein; MYT1; KIAA0835, KIAA1050, MTF1, MYTI, PLPB1;

Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up- regulation of myelin gene transcription.