Anti-ERCC8 Antibody
Boster Bio Anti-ERCC8 Antibody catalog # A04153. Tested in WB applications. This antibody reacts with Mouse.
Product Specifications
Synonyms
DNA excision repair protein ERCC-8; Cockayne syndrome WD repeat protein CSA; ERCC8; CKN1, CSA;
Gene Name
ERCC8
UniProt
Q13216
Host
Rabbit
Reactivity
Mouse
Immunogen
A synthetic peptide of human ERCC8 (NP_000073.1) .
Clonality
Polyclonal
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:500-1:2000
Form
Liquid
Function
Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX (ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription- coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.
Molecular Weight
44055 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
DNA excision repair protein ERCC-8
Subcellular Location
Nucleus .
Protein Name
DNA excision repair protein ERCC-8
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