Anti-GABAA R Beta 2 (R431) GABRB2 Antibody

Boster Bio Anti-GABAA R Beta 2 (R431) GABRB2 Antibody catalog # A04049. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Gamma-aminobutyric acid receptor subunit beta-2; GABA (A) receptor subunit beta-2; GABRB2;

Gene Name

GABRB2

UniProt

P47870

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide, corresponding to amino acids 400-450 of Human GABAA Rβ2.

Clonality

Polyclonal

Tissue Specificity

Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.

Applications

WB, IHC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Form

Liquid

Function

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel.