Anti-PRDM14 Antibody

Boster Bio Anti-PRDM14 Antibody catalog # A03870-1. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

PR domain zinc finger protein 14;2.1.1.-; PR domain-containing protein 14; PRDM14;

Gene Name

PRDM14

UniProt

Q9GZV8

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein of human PRDM14 (NP_078780.1) .

Clonality

Polyclonal

Tissue Specificity

Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level) .

Applications

WB, IHC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Form

Liquid

Function

Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity) . Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.