Anti-Atrophin-1 ATN1 Antibody
Boster Bio Anti-Atrophin-1 ATN1 Antibody catalog # A03828-2. Tested in WB, ICC, IP applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Atrophin-1; Dentatorubral-pallidoluysian atrophy protein; ATN1; D12S755E, DRPLA;
Gene Name
ATN1
UniProt
P54259
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 135-180 of Human Atrophin-1.
Clonality
Polyclonal
Tissue Specificity
Widely expressed in various tissues including heart, lung, kidney, ovary, testis, prostate, placenta, skeletal Low levels in the liver, thymus and leukocytes. In the adult brain, broadly expressed in amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus, and thalamus. High levels in fetal tissues, especially brain.
Applications
WB, ICC, IP
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity) . Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats.
Molecular Weight
125414 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A03828-2
Product MSDS
https://www.bosterbio.com/msds?sku=A03828-2
Other Gene Names
Atrophin-1
Subcellular Location
Nucleus. Cytoplasm, perinuclear region. Cell junction . Shuttles between nucleus and cytoplasm. Colocalizes with FAT1 in the perinuclear area, at cell- cell junctions and leading edges of cells (By similarity) . Colocalizes with MTG8 in discrete nuclear dots. Proteolytic fragment F1 appears to remain in nucleus. Fragment F2 is exported into the cytoplasm. Fragment F2 from mutant sequences with longer poly-Gln (polyQ) tracts are additionally located to the cytoplasmic membrane and to certain organelles. .
Protein Name
Atrophin-1
Curated Selection
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