Anti-KIR2DL4 Antibody

Killer cell immunoglobulin-like receptor 2DL4; CD158 antigen-like family member D; G9P; Killer cell inhibitory receptor 103AS; KIR-103AS; MHC class I NK cell receptor KIR103AS; CD158d

Expressed in decidual NK cells and innate lymphoid cell type I (ILC1) (PubMed:29262349) . Expressed in a subset of peripheral NK cells (PubMed:19304799) .

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) . In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734) . May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:16366734) . Upon interaction with peptide- bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent proinflammatory response (PubMed:20179272) .