Anti-SUN1 Antibody

As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (PubMed:18039933, PubMed:18396275) . The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity) . Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (By similarity) . Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (By similarity) . Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (By similarity) . Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity) . Required for efficient localization of SYNE4 in the nuclear envelope (By similarity) . May be involved in nuclear remodeling during sperm head formation in spermatogenenis (By similarity) . May play a role in DNA repair by suppressing non- homologous end joining repair to facilitate the repair of DNA cross-links (PubMed:24375709) .