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Anti-VRK1 Antibody

Boster Bio Anti-VRK1 Antibody catalog # A03396. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Serine/threonine-protein kinase VRK1;2.7.11.1; Vaccinia-related kinase 1; VRK1;

Gene Name

VRK1

UniProt

Q99986

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human VRK1.

Clonality

Polyclonal

Tissue Specificity

Widely expressed. Highly expressed in fetal liver, testis and thymus.

Applications

WB, IHC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Form

Liquid

Function

Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr- 18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.

Molecular Weight

45476 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

Serine/threonine-protein kinase VRK1

Subcellular Location

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle . Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.

Protein Name

Serine/threonine-protein kinase VRK1

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