Anti-CaMKII Alpha / Delta (M281) CAMK2A Antibody

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca (2+) /calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity) . Regulates dendritic spine development (PubMed:28130356) . Also regulates the migration of developing neurons (PubMed:29100089) . Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378) .