Anti-EFP (D222) TRIM25 Antibody
Boster Bio Anti-EFP (D222) TRIM25 Antibody catalog # A03232-3. Tested in WB, IHC applications. This antibody reacts with Human.
Product Specifications
Synonyms
E3 ubiquitin/ISG15 ligase TRIM25;6.3.2.n3
Gene Name
TRIM25
UniProt
Q14258
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide, corresponding to amino acids 360-418 of Human EFP.
Clonality
Polyclonal
Tissue Specificity
Expressed in breast tumors (at protein level) . Ubiquitous.
Applications
WB, IHC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784) .
Molecular Weight
70973 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
E3 ubiquitin/ISG15 ligase TRIM25
Subcellular Location
Cytoplasm
Protein Name
E3 ubiquitin/ISG15 ligase TRIM25
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