Anti-LTBP1 Antibody
Boster Bio Anti-LTBP1 Antibody catalog # A03224. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Latent-transforming growth factor beta-binding protein 1
Gene Name
LTBP1
UniProt
Q14766
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues in Human LTBP1
Clonality
Polyclonal
Tissue Specificity
Expressed in the aorta (at protein level) (PubMed:17293099) . Isoform Long: Expressed in fibroblasts (PubMed:17293099) .
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:500-1:1000
Form
Liquid
Function
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931) . Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:8617200, PubMed:8939931, PubMed:15184403) . Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742) .
Molecular Weight
186796 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Latent-transforming growth factor beta-binding protein 1
Subcellular Location
Secreted
Protein Name
Latent-transforming growth factor beta-binding protein 1
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