Anti-Protein unc-13 homolog D UNC13D Antibody

Boster Bio Anti-Protein unc-13 homolog D UNC13D Antibody catalog # A03088. Tested in WB applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Protein unc-13 homolog D; Munc13-4; UNC13D;

Gene Name

UNC13D

UniProt

Q70J99

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant fusion protein of human UNC13D (NP_954712.1) .

Clonality

Polyclonal

Tissue Specificity

Expressed at high levels in spleen, thymus and leukocytes. Also expressed in lung and placenta, and at very low levels in brain, heart, skeletal muscle and kidney. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.

Applications

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Dilution

WB: 1:1000-1:2000

Form

Liquid

Function

Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca (2+) -dependent secretory lysosome exocytosis in mast cells.

Molecular Weight

123282 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

Protein unc-13 homolog D

Subcellular Location

Cytoplasm. Membrane; Peripheral membrane protein. Late endosome. Recycling endosome. Lysosome. Colocalizes with cytotoxic granules at the plasma membrane. Localizes to endosomal exocytic vesicles.