Anti-Dok-1 (P356) Antibody
Boster Bio Anti-Dok-1 (P356) Antibody catalog # A03039-2. Tested in IHC, IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Docking protein 1; Downstream of tyrosine kinase 1; p62 (dok) ; pp62; DOK1;
Gene Name
DOK1
UniProt
Q99704
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 322-370 of Human Dok-1.
Clonality
Polyclonal
Tissue Specificity
Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.
Applications
IHC, IF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
Molecular Weight
52392 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Docking protein 1
Subcellular Location
Isoform 1: Cytoplasm. Nucleus.
Protein Name
Docking protein 1
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