Anti-ERK5 MAPK7 Antibody
Boster Bio Anti-ERK5 MAPK7 Antibody catalog # A02812-1. Tested in WB, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Mitogen-activated protein kinase 7; MAP kinase 7; MAPK 7;2.7.11.24; Big MAP kinase 1; BMK-1; Extracellular signal-regulated kinase 5; ERK-5; MAPK7; BMK1, ERK5, PRKM7;
Gene Name
MAPK7
UniProt
Q13164
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein
Clonality
Polyclonal
Tissue Specificity
Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver.
Applications
WB, ICC, IF, IP, Flow Cytometry
Purification
ProA affinity purified
Form
Liquid
Function
Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras- independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.
Molecular Weight
88386 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Mitogen-activated protein kinase 7
Subcellular Location
Cytoplasm. Nucleus. Nucleus, PML body. Translocates to the nucleus upon activation.
Protein Name
Mitogen-activated protein kinase 7
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
