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Anti-Granzyme A GZMA Antibody

Boster Bio Anti-Granzyme A GZMA Antibody catalog # A02779. Tested in WB, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Granzyme A;3.4.21.78; CTL tryptase; Cytotoxic T-lymphocyte proteinase 1; Fragmentin-1; Granzyme-1; Hanukkah factor; H factor; HF; GZMA; CTLA3, HFSP;

Gene Name

GZMA

UniProt

P12544

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant full length Human GZMA.

Clonality

Polyclonal

Applications

WB, IF

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Form

Liquid

Function

Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.

Molecular Weight

28999 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A02779

Product MSDS

https://www.bosterbio.com/msds?sku=A02779

Other Gene Names

Granzyme A

Subcellular Location

Isoform alpha: Secreted. Cytoplasmic granule.

Protein Name

Granzyme A

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