Anti-Ephrin-B1 (phospho-Y317) EFNB1 Antibody

Widely expressed (PubMed:8070404, PubMed:7973638) . Detected in both neuronal and non-neuronal tissues (PubMed:8070404, PubMed:7973638) . Seems to have particularly strong expression in retina, sciatic nerve, heart and spinal cord (PubMed:7973638) .

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development (PubMed:8070404, PubMed:7973638) . Binding to Eph receptors residing on adjacent cells leads to contact- dependent bidirectional signaling into neighboring cells (PubMed:8070404, PubMed:7973638) . Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (PubMed:8070404, PubMed:7973638) . Can also bind EPHB2 and EPHB3 (PubMed:8070404) . Binds to, and induces collapse of, commissural axons/growth cones in vitro (By similarity) . May play a role in constraining the orientation of longitudinally projecting axons (By similarity) .